Defining osteoarthritis: a moving target

Defining osteoarthritis: a moving target.

1063-4584/$ – see front matter 2011 Osteoarthritis doi:10.1016/j.joca.2011.10.008 The challenge of disease definition in osteoarthritis (OA) continues to grow. As described by Pereira et al., in a recent issue of Osteoarthritis and Cartilage (OAC), there are substantial differences in prevalence and incidence estimates when defining OA by radiographic changes alone, as symptomatic OA (requiring...

a novel navigation method for pursuing a moving target

the most current pursuit algorithms for moving targets which are presented so far in the literatureare pure pursuit and pure rendezvous navigations. recently, one of the present authors has introduced ageometric model for the pure pursuit navigation algorithm. here, in this paper, we study a new algorithm forthe pursuit navigation problem which is a combination of both of the above algorithms. ...

Glioblastoma—a moving target

The slow development of effective treatment of glioblastoma is contrasted by the rapidly advancing research on the molecular mechanisms underlying the disease. Amplification and overexpression of receptor tyrosine kinases, particularly EGFR and PDGFRA, are complemented by mutations in the PI3K, RB1, and p53 signaling pathways. In addition to finding effective means to target these pathways, we ...

ERP a moving target

Enterprise Resource Planning systems are central elements in longterm wide-ranging design and use networks. Present ERP research focuses on single-enterprise implementation and fails to address important features of the ERP networks such as multi-spatiality, the design of the generic and the dynamics over time. A six-field matrix is proposed as a conceptual frame, encompassing shortand long-ter...

Defining Integrated Knowledge Translation and Moving Forward: A Response to Recent Commentaries